Atrial fibrillation ablation has emerged as an effective tool in the management of symptomatic atrial fibrillation. Currently, the eletrophysiologists are striving to maximize the success while minimizing complications. Phrenic nerve injury (PNI) is one of the concerning complications, especially in cases of cryo-balloon ablation. Due to anatomical proximity to atrial tissue, phrenic nerve is particularly susceptible to injury. With evolving monitoring techniques it is now possible to minimize the likelihood of a permanent PNI. However, the challenge remains to detect PNI at the earliest and to avoid further damage to the nerve. In this review, we discuss pertinent anatomical principles, techniques to avoid PNI and management in cases where PNI is encountered.