The problem with the regulation of the autonomic nervous system or paroxysmal reflex vagal activation episodes may have an important role in the pathophysiology of vasovagal syncope (VVS), sinus bradycardia or periods of sinus arrest, and variable-degree atrioventricular block (AVB). Because existence of structural heart disease tends to shift the vagosympathetic balance towards a sympathetic predominance, vagally-mediated bradyarrhythmias (VMB) usually occurs in young individuals with structurally normal hearts. However, similar reflex problems may be observed in the elderly people and even those with structural heart disease. Modification of the efferent arm of autonomic nervous system by ablation of main ganglionated plexi (GPs) is called as cardioneuroablation (CNA) and seems as a promising treatment option for appropriately selected patients with VMB. This review outlines the process of patient selection for CNA on the basis of supporting evidence.