Our sincere condolences to those who lost their loved ones to the second wave of COVID sweeping across the world. Just about as the world was about to get a break from ayearlong carnage that this tricky microbe has caused, we are seeing incredibly discouraging news from India and other places. We cannot underestimate the ability of this virus to mutate and continue to infect humanity. As the vaccination program gets a solid footing, we should continue our efforts to enforce appropriate social distancing, masking, and disinfection practices. The Center for Disease Control should exert some restrain in lifting the masking requirements in public places. There is a significant misinformation prevalent that is deterring people from embracing the COVID vaccination. Please educate your patients, family, friends, and neighbors to get vaccinated and change the course of this deadly pestilence.