increasing burden of Chronic Kidney Disease (CKD) is highly relevant to
cardiologists, as cardiovascular mortality is 10-30 times higher amongst people
with ESRD, comparing with general population. One of the commonest associations
is the increased frequency of atrial fibrillation (AF) amongst those
we know that AF is the most common cardiac arrhythmia. AF leads to a
substantial risk of mortality and morbidity, from stroke and thromboembolism,
heart failure, reduced cognitive function and impaired quality of life. However, most clinical trials in AF (for
example, for stroke prevention in AF with anticoagulation therapy) have largely
excluded patients with significant renal impairment.
this review article, we will focus on stroke prevention in AF, and the clinical
impact of CKD and its implications for management.
Credits: Yee C Lau; Gregory Y H Lip