fibrillation (AF) presently affects over 2 million Americans, and the magnitude
and population burden from AF continues to increase concomitant with the aging
of the U.S. population. Chronic kidney disease (CKD) is present in 13% of
individuals in the U.S., and the prevalence of CKD is also rapidly increasing.
The increasing population burden of CKD and AF will profoundly affect the
clinical and public health, since CKD and AF are both associated with lower
quality of life, increased hospitalization rates, and a greater risk of heart
failure, stroke, and total mortality. AF and CKD often co-exist, each condition
predisposes to the other, and the co-occurrence of these disorders worsens
prognosis relative to either disease alone. The shared epidemiology of CKD and
AF may be explained by the strong pathophysiologic connections between these
diseases. In order to promote a better understanding of CKD and AF, we have
reviewed their shared epidemiology and pathophysiology and described the
natural history of patients affected by both diseases.
Credits: David D. McManus MD; Jane S. Saczynski PhD; Jeanine A. Ward MD PhD; Khushleen Jaggi MD, Peter Bourrell MD; Chad Darling MD; Robert J. Goldberg PhD