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Hyperuricemia and Risk for Atrial Fibrillation Yuansheng Liu


Atrial fibrillation (AF) is a clinically common arrhythmia and preferentially afflicts elderly persons[1]. The main risk factors for AF are complicated and multifactorial. Several clinical risk factors for the development of AF have been confirmed, including old age, male gender, rheumatic heart disease, hypertension, congestive heart failure, hyperthyroidism, chronic kidney disease and diabetes mellitus. Although the pathophysiology of AF remains incompletely understood, accumulative evidences indicated that oxidative stress and inflammation were involved in the process of atrial remodeling which predisposed patients to AF [2,3]. In addition, a consistent relationship between elevated serum uric acid (SUA) levels and circulating inflammatory markers has been reported.The association between SUA levels and AF is currently poorly known. In our previous study, the results also showed that low serum albumin and hyperuricemia were independently correlated with the presence of AF compared with the non-AF group[4]. Previous studies support the hypothesis that hyperuricemia causes vascular disease via endothelial dysfunction. It is clear that further studies are needed to determine whether the SUA level increases the risk of AF directly or indirectly[4,5].

Credits: Dr. Yuansheng Liu



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