Atrial fibrillation (AF) is a clinically common
arrhythmia and preferentially afflicts elderly persons[1]. The main risk factors for AF are complicated and multifactorial. Several
clinical risk factors for the development of AF have been confirmed, including old age, male gender, rheumatic heart disease, hypertension, congestive heart failure, hyperthyroidism, chronic kidney disease and diabetes mellitus. Although the
pathophysiology of AF remains incompletely understood, accumulative evidences indicated
that oxidative stress and inflammation were involved in the process of atrial remodeling which predisposed
patients to AF [2,3]. In
addition, a consistent relationship between elevated serum uric acid (SUA) levels and
circulating inflammatory markers has been reported.The association
between SUA levels and AF is currently poorly known. In our previous study, the
results also showed that low serum albumin and hyperuricemia were independently correlated with the presence
of AF compared with the non-AF group[4]. Previous studies support the
hypothesis that hyperuricemia causes vascular disease via endothelial
dysfunction. It is clear that further studies are needed to determine whether
the SUA level increases the risk of AF directly or indirectly[4,5].
Credits: Dr. Yuansheng Liu